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Congratulations to Dr. Wendy Wu on the successful defense of her thesis:

"Coupling Between KNQ/M-channels and L-type Ca2+Channels as a Substrate for a Novel, Activity-Dependent Intrinsic Plasticity"

 

and to

Dr. Amy Gamelli Kuo on the successful presentation of her dissertation:
"Modulation and Cellular Mechanisms of Hippocampal Learning"

 
 
 
First nourishing meal in two months...
 
 
 
 
Still Defending...
 
 
 
 
Congratulations, Wendy and Amy!!!
 
     
     
     
 

 
 
 

 

HAPPY BIRTHDAY!! Bob and John

View the Pix from the **Mechanisms of Aging and Dementia Training Grant Day***
Friday, February 11, 2005
Peninsula Hotel, 108 E Superior (at N Michigan Ave), Chicago
Click Here
Honoraria:
2005 Inaugural Lecturer, "Understanding and Enhancing Learning Abilities in the Aging Brain," Manoa Colloquium, University of Hawaii, Honolulu, Hawaii, February 22, 2005

Rotating Students in Dr. Disterhoft's lab this academic year include:
Fall: Mariana Jimenez and Aaron Schain
Winter:
Luke Flores, Yoonsoo Kim and Bridget McKay

Visiting Researchers:
Jim Kehoe returned from Australia for a brief visit, and presented a departmental seminar entitled "Extinction:Context Can Make All the Difference and None at All" on July 6, 2004.


New Funding:

A Society for Neuroscience Minority Neuroscience Fellowship Program (SFN-MNFP):
for Robert Galvez. The funding will extend from 4/1/05 through 3/31/07,in support of Robert's research to characterize learning induced cortical plasticity as a function of age. Specifically, he has been working on establishing and subsequently characterizing cortical changes in response to eyeblink conditioning with vibrissae stimulation as the conditioned stimulus in rabbits.

From the National Institutes of Health:

John Desmond, PI, John Disterhoft, Co-Investigator 6/01/04-5/31/09
fMRI Analysis of Aging and Awareness in Conditioning
A new application to apply fMRI studies of the BOLD response in human brain during acquisition of eyeblink conditioning. The brain systems underlying learning and awareness will be visualized in young and aging subjects using the 3 Tesla magnet at the Lucas Imaging Center of Stanford University. NIA#

Geinisman, PI; Disterhoft, Co-Investigator. 9/1/99 - 8/31/09
Synaptic Substrates of Age-Dependent Memory Deficits
The goals of this project are to investigate the synaptic mechanisms of age-related deficits in learning with a combination of unbiased quantitative electron microscopic, behavioral and electrophysiological techniques applied to the CA1 and dentate regions of the hippocampus. NIA#R01 AG021501, John Desmond, PI, John Disterhoft, Co-Investigator 6/01/04-5/31/09
fMRI Analysis of Aging and Awareness in Conditioning.NIA# 1 R01 AG17139


For Dr. Disterhoft's competetive renewal application "Forebrain Cerebellar Interactions During Learning". This is a single neuron recording and reversible lesion study investigating the function of sites on the pathway by which forebrain and cerebellum interact during hippocampally dependent trace eyeblink conditioning and during consolidation of the learning response.

For "Neurophysiological Bases of functional MRI signals". This was a new application designed to examine the generation of the BOLD response in functional magnetic resonanace imaging with a combination of imaging and neurophysiological techniques in the conscious, restrained rabbit.

For Dr. Masuo Ohno's new funding CaMKII and Neuronal Excitability Changes in Learning

For the competetive renewal of Dr. Disterhoft's Merit Award from the NIA for his project Slow Outward Currents and Learning in Aging Hippocampus


New Lab Members:

Dr. CJ Han joined the lab in Mid-November of 2003. She received her Ph.D. in Psychology from SUNY Stonybrook, and most recently completed postdoctoral studies at CalTech under Cristof Koch and David Anderson.

Roberto Galvez joined the lab on April 1, 2004. He recently completed his Ph.D. with Dr. William Greenough at the University of Illinois in Urbana/Champaign and is taking a postdoctoral position in Dr. Disterhoft's Mechanisms of Aging and Dementia Training Program.

On a More Personal Note:

Dr. Aldis Weible and Rie Yoshida were recently married in a traditional Japanese ceremony in Rie's home city of Osaka, Japan.

CLICK HERE to view a nationally broadcast synopsis of recent findings aired by ScienCentral in January 2004. The research was done by Dr. Masuo Ohno. Funding for the relevant research grant, entitled "Interactions of APP and BACE on Behavior and Hippocampal Physiology in Aging Mice" was initiated and continues to be funded by the Alzheimer's Association and was published in Neuron, 2004, 41, 27-33.



 

Dr. John Disterhoft
Department of Physiology  -  Institute for Neuroscience
Northwestern University Feinberg School of Medicine

303 East Chicago Ave., Chicago, IL 60611-3008
Telephone: 312-503-7982   Fax: 312-503-2090

E-Mail: jdisterhoft@northwestern.edu

Directions to the Disterhoft Lab

 

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Last updated: Tuesday, Feb 1,, 2005